Attia separates acute from chronic inflammation, works through which inflammatory markers are actually worth measuring versus which are noise, and what genuinely lowers chronic inflammatory burden. A practical counterpart to the mechanistic literature.
Listen →Andrew Huberman talks with mitochondria researcher Dr. Jared Rutter (University of Utah, HHMI) about how mitochondria generate cellular energy, regulate cell growth and division, and link to aging and cancer. The conversation frames metabolism as an emergent property of trillions of individual mitochondria-containing cells.
Listen →An investigation into the science — and the gaps in the science — behind BPC-157 and MOTS-c, including a look at the risks people rarely ask about.
Listen →Dr. Martin Picard (Columbia) explains how mitochondria translate behavior, psychology, and mindset into cellular energy production, and how exercise, nutrition, sleep, and stress reduction measurably affect mitochondrial function and aging markers.
Listen →Dr. Martin Picard (Columbia) explains how mitochondria translate behavior, psychology, and mindset into cellular energy production, and how exercise, nutrition, sleep, and stress reduction measurably affect mitochondrial function and aging markers.
Listen →Eric Verdin, CEO of the Buck Institute for Research on Aging, on how immune aging — thymic shrinkage, narrowing T-cell diversity, weaker vaccine response — acts as a rate-limiting step in aging, and how chronic inflammation is both a consequence and an accelerant of it. Also covers NAD decline and CD38, the real limits of NMN/NR/IV NAD, rapamycin, and what aging clocks can and can't tell you.
Listen →A three-hour deep dive with metabolic researcher Ben Bikman on what actually drives insulin resistance, why insulin matters as a measure independently of glucose, how diet, exercise and sleep each move the needle, and where GLP-1 agonists fit into the picture. Hosted by Rhonda Patrick.
Listen →A three-hour deep dive with metabolic researcher Ben Bikman on what actually drives insulin resistance, why insulin matters as a measure independently of glucose, how diet, exercise and sleep each move the needle, and where GLP-1 agonists fit into the picture. Hosted by Rhonda Patrick.
Listen →Pools 13 systematic reviews (11 with meta-analyses) covering resistance, aerobic, combined, HIIT, tai chi, yoga and multimodal training in older adults. Exercise reliably lowered CRP across every review, with resistance training performing best, and reduced TNF-α in most reviews, with HIIT showing particular promise. IL-6 results were inconsistent, with combined aerobic-plus-resistance training doing best, and there was too little data to judge IL-10.
Read source →Huberman and Attia dig into the NAD+ pathway, comparing NAD, NMN, and NR supplementation, routes of administration, and what the clinical literature actually supports for longevity.
Listen →Bikman's short-format lecture series on the practical side: which tests actually surface insulin resistance (and why fasting glucose alone routinely misses it), plus what changes it. Tighter and more focused than the long-form interviews.
Listen →This PRISMA systematic review pooled 113 studies (33 human, 80 rodent) on NAD+-boosting compounds like NR and NMN. It found rodent studies often showed metabolic and mitochondrial benefits, but in humans, oral NR/NMN reliably raised NAD+-related biomarkers while effects on real functional and health outcomes were mixed or null, and no outcomes trials existed yet for IV/wellness-clinic NAD+ infusions.
Read source →A widely-read explainer on how glucose tolerance and mitochondrial energy output decline with age, and the practical levers (diet, exercise, sleep) with the most human evidence behind them for preserving metabolic health.
Read source →An evergreen research hub tracking the evidence base for Urolithin A as a mitophagy-inducing postbiotic, updated as new studies land.
Read source →This narrative review synthesizes mechanistic and preclinical evidence that the supplement PQQ activates mitochondrial biogenesis pathways (CREB, PGC-1a, TFAM) and protects against oxidative injury, applying that evidence to skin aging and recovery after aesthetic procedures. The authors note the dermatology-specific human evidence base is still thin relative to the preclinical mechanism data.
Read source →Reviews dietary approaches to insulin resistance. The Mediterranean diet has the strongest evidence, with consistent HOMA-IR reductions and a 31% lower type 2 diabetes incidence in PREDIMED-Plus. Low-carbohydrate and ketogenic diets produce the largest short-term drops in fasting glucose and insulin, but their sustainability is unclear. The authors caution that most studies use surrogate indices, last 26 weeks or less, and struggle to separate diet effects from weight loss.
Read source →A condensed Huberman Lab episode with Rhonda Patrick on four micronutrients that influence cellular stress responses, inflammation, detoxification and longevity, and why common shortfalls in them may matter more than people assume.
Listen →NYT's David Dodge and McGill's Jonathan Jarry unpack why injectable peptide therapy caught fire in the wellness world despite thin safety data.
Listen →This narrative review examines how heat acclimation protocols alter mitochondrial biogenesis and bioenergetic function across cell, rodent, and human studies, and links those subcellular changes to exercise performance gains. The authors propose a heat-acclimation protocol designed to maximize mitochondrial adaptation and flag open questions for future research.
Read source →A deep dive into Zone 2 training dose, frequency, and duration, and how it drives mitochondrial biogenesis and oxidative capacity.
Listen →A masterclass on energy system pathways, fuel sources, exercise training zones, and mitochondrial function as both a diagnostic and treatment target for metabolic health.
Listen →