Research Resources

ICONIC-ADVANCE 1 and 2: icotrokinra versus deucravacitinib in plaque psoriasis

Pemvidutide preserves lean mass with weight loss of nearly 16% — MOMENTUM Phase 2 trial

Pemvidutide demonstrates significant metabolic improvements — IMPACT 48-week data

Viking Therapeutics presents 13-week Phase 2 VENTURE-Oral dosing trial of VK2735

VENTURE Phase 2 trial of subcutaneous VK2735 in obesity

Icotrokinra: First Approval

FDA prescribing information — FOUNDAYO (orforglipron)

Novo Nordisk advances amycretin to Phase 3 clinical development based on early-phase results

Amycretin Phase 1b/2a trial in obesity

Pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron

FDA prescribing information — YORVIPATH

Preclinical pharmacology of JNJ-77242113, an oral IL-23 receptor antagonist peptide

Efficacy and safety of palopegteriparatide (TransCon PTH) at 52 weeks — PaTHway trial

A new dawn in research: FDA approves pegulicianine for fluorescence-guided surgery in breast cancer patients

GK-2 selectively activates TrkA over TrkB: knockout cell line study

Igarashi M et al. (2022) — Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels in healthy older men

Tirzepatide Once Weekly for the Treatment of Obesity

Igarashi M et al. (2022) — Chronic NMN supplementation elevates blood NAD+ levels in healthy older men

Igarashi M et al. (2022) — Chronic NMN supplementation elevates blood NAD+ levels in healthy older men

GSB-106 reverses anhedonia in a chronic social defeat stress model (oral dosing)

Thymosin alpha-1 in COVID-19 critically ill patients: a systematic review

Yoshino J et al. (2021) — Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Plasma LEAP2 is elevated in adults with obesity and is associated with insulin resistance

Liao B et al. (2021) — Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners

Yoshino M et al. (2021) — Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Yoshino M et al. (2021) — Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Liao B et al. (2021) — Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners

GSB-106 promotes TrkB-dependent cell survival

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes

The mitochondrial-derived peptide humanin is a regulator of lifespan and healthspan

Kisspeptin-54 triggers egg maturation in IVF patients with apparent low risk of OHSS

The mitochondria-targeted peptide SS-31 improves mitochondrial function and reduces oxidative stress in aged skeletal muscle

Design and Preclinical Development of TransCon PTH

N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor

Elhassan YS et al. (2019) — Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome

Sikiric P et al. (2018) — BPC-157 cytoprotective and growth factor modulation review

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor

Sikiric P et al. (2018) — BPC-157 cytoprotective and growth factor modulation review

Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157. A medicine for various target organs

Stable gastric pentadecapeptide BPC 157 can improve the healing of muscle, tendon, and bone defects

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Intranasal vasoactive intestinal peptide improves symptoms and biomarkers in CIRS patients

Mills KF et al. (2016) — Long-term administration of NMN mitigates age-associated physiological decline in mice

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

Elamipretide (MTP-131) alleviates LPS-induced septic cardiomyopathy by inhibiting oxidative stress and NLRP3 inflammasome activation

Mills KF et al. (2016) — Long-term administration of NMN mitigates age-associated physiological decline in mice

Pickart L et al. (2015) — GHK-Cu and gene expression: 4,000 gene modulation toward younger phenotype

Pentadecapeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine

Pickart L et al. (2015) — GHK-Cu collagen gene activation and anti-aging review

Pickart L et al. (2015) — GHK-Cu and gene expression: 4,000 gene modulation toward younger phenotype

Imai S & Guarente L (2014) — NAD+ and sirtuins in aging and disease

Imai S & Guarente L (2014) — NAD+ and sirtuins in aging and disease

Imai S & Guarente L (2014) — NAD+ and sirtuins in aging and disease

Original characterization of the antidepressant-like effect of GSB-106

Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions

GK-2 restores cognitive function in a rat model of Alzheimer's-like pathology

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) greatly enhances memory in rats

Cantó C et al. (2012) — The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

Goldstein AL et al. (2012) — Thymosin β4 promotes wound repair and angiogenesis

Goldstein AL et al. (2012) — Thymosin β4 promotes wound repair and angiogenesis

Delivery of α-MSH peptide in nanoparticles for the resolution of intestinal inflammation

Adropin reduces blood pressure and increases endothelial nitric-oxide synthase activity via the ERK1/2–PI3K–Akt signaling pathway

Inhaled vasoactive intestinal peptide exerts immunomodulatory effects in sarcoidosis

Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity

Oxytocin enhances the experience of attachment security

Selank — a synthetic analogue of tuftsin with nootropic and anxiolytic activity

Anxiolytic effect of Selank peptide in patients with anxiety-phobic disorders

Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: A randomized trial

Smart N et al. (2007) — Thymosin β4 cardiac repair and angiogenesis

Development of α-MSH analogues for the treatment of sexual dysfunction

LL-37: The only human member of the cathelicidin family of antimicrobial peptides

Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?

Melanotan II: a melanotropic peptide with potent melanogenic and sexual effects

Kisspeptin as a novel therapeutic target for reproductive axis disorders

Oxytocin increases trust in humans

Catania A et al. (2004) — KPV and MC1R anti-inflammatory signalling in skin

The role of oxytocin in pair bonding and social behaviour

Growth hormone-releasing hormone and its analogues: therapeutic perspectives

Peptide Bioregulators Prolong Human Life: First Actual Data

The antimicrobial peptide LL-37 promotes wound healing in skin via multiple mechanisms

Twenty years of study on peptide regulation of aging

Growth hormone-independent cardioprotective effects of hexarelin in the rat

Humanin: A novel neuroprotective factor against Alzheimer's disease

Two-month treatment with the growth hormone secretagogue MK-677 increases insulin-like growth factor 1 and growth hormone in elderly adults

Thymalfasin (thymosin alpha 1): a new therapeutic option for hepatitis B and C

Hexarelin, a synthetic GH-releasing peptide, stimulates GH secretion in GH-deficient subjects

Sustained pulsatile growth hormone (GH) secretion in normal men after administration of releasing peptide GHRP-6

Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone

Delta sleep-inducing peptide (DSIP): a review

A sleep-inducing peptide isolated from the blood of sleeping rabbits

Thymosin alpha-1: biological activity and clinical applications