Evidence-based cycling protocols for each peptide — including recommended on-cycle duration, off-cycle breaks, dosing, and tolerance considerations.
Research use only. Cycle protocols are based on available preclinical data, published research, and community practice. Always consult a licensed physician before starting any peptide protocol. Not approved for human therapeutic use in most jurisdictions.
Receptor downregulation, tolerance development, and preservation of long-term sensitivity are the primary reasons to cycle peptides. Off-periods allow the body's signaling systems to reset.
Off-cycles prevent receptor saturation, allow assessment of persistent benefits, and reduce the risk of unknown long-term effects from continuous use of poorly-studied compounds.
Semaglutide, Tirzepatide, and Tesamorelin are FDA-approved and intended for continuous use under physician supervision. They follow prescribing guidelines, not cycling protocols.
23 PEPTIDES