Also known as: EDR peptide · Glu-Asp-Arg · Epithalon sister peptide
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) derived from the pineal gland that exhibits neuroprotective and nootropic properties. Developed alongside Epithalon by the St. Petersburg Institute of Bioregulation, it penetrates the blood-brain barrier and promotes neuronal repair, improves memory, and modulates circadian rhythms.
Pinealon (EDR) is a tripeptide developed by the St. Petersburg Institute of Bioregulation and Gerontology. It is derived from pineal gland proteins and has demonstrated neuroprotective effects in ischaemia models, cognitive improvement in aged animals, and circadian rhythm modulation. Its small size (3 amino acids) allows efficient blood-brain barrier penetration.
Pinealon penetrates the blood-brain barrier and enters neurons where it acts as a gene-regulatory peptide, binding to DNA promoter regions and modulating expression of neuroprotective genes. It upregulates antioxidant enzymes (SOD, catalase), inhibits mitochondrial apoptotic pathways, and modulates melatonin synthesis in the pineal gland.
Pinealon is a peptide bioregulator in the tradition of Epithalon and Semax. Limited Western clinical data; most research is from the St. Petersburg Institute of Bioregulation. Generally well-tolerated. Best used in 10–30 day courses, 2–3 times per year. Often combined with Epithalon for comprehensive longevity protocols.
Russian peptide bioregulator protocol: 10-day courses, 2–4 times per year. Often combined with Epithalon (spring and autumn). Effects on sleep and cognition may be most noticeable in the first week of a course.
Typically administered as intranasal drops or subcutaneously. Standard course: 10–100 mcg/day for 10–30 days. Often combined with Epithalon in longevity protocols. Well-tolerated with no significant adverse events in available literature.
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