Pools 13 systematic reviews (11 with meta-analyses) covering resistance, aerobic, combined, HIIT, tai chi, yoga and multimodal training in older adults. Exercise reliably lowered CRP across every review, with resistance training performing best, and reduced TNF-α in most reviews, with HIIT showing particular promise. IL-6 results were inconsistent, with combined aerobic-plus-resistance training doing best, and there was too little data to judge IL-10.
Read source →López-Otín, Blasco, Partridge, Serrano & Kroemer expand the hallmarks of aging from 9 to 12, including mitochondrial dysfunction — and map how each hallmark reinforces the others.
Read source →An evergreen research hub tracking the evidence base for Urolithin A as a mitophagy-inducing postbiotic, updated as new studies land.
Read source →A 2026 Nature Metabolism review of how mitophagy, biogenesis, and mitochondrial network dynamics change with age, and what that means for healthspan interventions targeting mitochondrial quality rather than just quantity.
Read source →This PRISMA systematic review pooled 113 studies (33 human, 80 rodent) on NAD+-boosting compounds like NR and NMN. It found rodent studies often showed metabolic and mitochondrial benefits, but in humans, oral NR/NMN reliably raised NAD+-related biomarkers while effects on real functional and health outcomes were mixed or null, and no outcomes trials existed yet for IV/wellness-clinic NAD+ infusions.
Read source →This narrative review synthesizes mechanistic and preclinical evidence that the supplement PQQ activates mitochondrial biogenesis pathways (CREB, PGC-1a, TFAM) and protects against oxidative injury, applying that evidence to skin aging and recovery after aesthetic procedures. The authors note the dermatology-specific human evidence base is still thin relative to the preclinical mechanism data.
Read source →Reviews dietary approaches to insulin resistance. The Mediterranean diet has the strongest evidence, with consistent HOMA-IR reductions and a 31% lower type 2 diabetes incidence in PREDIMED-Plus. Low-carbohydrate and ketogenic diets produce the largest short-term drops in fasting glucose and insulin, but their sustainability is unclear. The authors caution that most studies use surrogate indices, last 26 weeks or less, and struggle to separate diet effects from weight loss.
Read source →This narrative review examines how heat acclimation protocols alter mitochondrial biogenesis and bioenergetic function across cell, rodent, and human studies, and links those subcellular changes to exercise performance gains. The authors propose a heat-acclimation protocol designed to maximize mitochondrial adaptation and flag open questions for future research.
Read source →Maps how age-associated chronic inflammation interacts with the other eleven hallmarks of aging, arguing the crosstalk forms a self-reinforcing cycle that accelerates cellular decline. A good orientation piece for why inflammation sits near the centre of the aging network rather than off to one side.
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