López-Otín, Blasco, Partridge, Serrano & Kroemer expand the hallmarks of aging from 9 to 12, including mitochondrial dysfunction — and map how each hallmark reinforces the others.
Read source →An evergreen research hub tracking the evidence base for Urolithin A as a mitophagy-inducing postbiotic, updated as new studies land.
Read source →A 2026 Nature Metabolism review of how mitophagy, biogenesis, and mitochondrial network dynamics change with age, and what that means for healthspan interventions targeting mitochondrial quality rather than just quantity.
Read source →This PRISMA systematic review pooled 113 studies (33 human, 80 rodent) on NAD+-boosting compounds like NR and NMN. It found rodent studies often showed metabolic and mitochondrial benefits, but in humans, oral NR/NMN reliably raised NAD+-related biomarkers while effects on real functional and health outcomes were mixed or null, and no outcomes trials existed yet for IV/wellness-clinic NAD+ infusions.
Read source →This narrative review synthesizes mechanistic and preclinical evidence that the supplement PQQ activates mitochondrial biogenesis pathways (CREB, PGC-1a, TFAM) and protects against oxidative injury, applying that evidence to skin aging and recovery after aesthetic procedures. The authors note the dermatology-specific human evidence base is still thin relative to the preclinical mechanism data.
Read source →This narrative review examines how heat acclimation protocols alter mitochondrial biogenesis and bioenergetic function across cell, rodent, and human studies, and links those subcellular changes to exercise performance gains. The authors propose a heat-acclimation protocol designed to maximize mitochondrial adaptation and flag open questions for future research.
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