A three-hour deep dive with metabolic researcher Ben Bikman on what actually drives insulin resistance, why insulin matters as a measure independently of glucose, how diet, exercise and sleep each move the needle, and where GLP-1 agonists fit into the picture. Hosted by Rhonda Patrick.
Listen →A three-hour deep dive with metabolic researcher Ben Bikman on what actually drives insulin resistance, why insulin matters as a measure independently of glucose, how diet, exercise and sleep each move the needle, and where GLP-1 agonists fit into the picture. Hosted by Rhonda Patrick.
Listen →Ralph DeFronzo, M.D. — the researcher who helped bring metformin to the US and developed SGLT2 inhibitors — walks through the pathophysiology of insulin resistance across muscle, liver, and fat, and how it's measured, prevented, diagnosed, and treated.
Listen →Ralph DeFronzo, M.D. walks through the pathophysiology of insulin resistance across muscle, liver, and fat, and how it's measured, prevented, diagnosed, and treated.
Listen →Bikman's short-format lecture series on the practical side: which tests actually surface insulin resistance (and why fasting glucose alone routinely misses it), plus what changes it. Tighter and more focused than the long-form interviews.
Listen →Attia and Huberman work through the research on metformin as a longevity drug. Along the way Attia explains how insulin resistance develops — starting in muscle — and its role in type 2 diabetes. A useful look at how to read the evidence behind a much-hyped intervention.
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