Also known as: Thymosin Beta-4 · Tβ4 · Thymosin-β4
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide found in virtually all human and animal cells. It plays a critical role in tissue repair, wound healing, and the regulation of actin polymerization.
Thymosin Beta-4 is one of the most abundant peptides in the body, with concentrations particularly high in platelets and wound fluid. TB-500 is a synthetic analog developed to mirror the biological activities of the naturally occurring protein.
Its unique capacity to promote cell migration and differentiation makes it particularly valuable in cardiac and skeletal muscle repair research. TB-500 has been studied extensively in animal models and is widely used in veterinary medicine for tendon and ligament injuries in racehorses.
TB-500's primary mechanism involves binding to actin via its central domain. By sequestering G-actin, TB-500 promotes cell migration, differentiation, and proliferation — all critical steps in wound healing.
TB-500 upregulates integrin receptors and metalloproteinase enzymes that break down the extracellular matrix, allowing newly formed cells to migrate into damaged tissue.
TB-500 is the synthetic analogue of the active fragment of Thymosin Beta-4, a naturally occurring peptide found in virtually all human and animal cells. It has a strong safety profile in animal research. No human clinical trials published. Store lyophilized powder at −20°C; reconstituted solution at 4°C for up to 30 days.
A typical protocol consists of a 4–6 week loading phase (twice weekly injections) followed by a maintenance phase or complete off-cycle. Many researchers take an extended break after loading and resume only if symptoms return. The long half-life means effects persist well beyond the last injection.
Ask anything about TB-500 — mechanisms, dosing protocols, interactions, or research comparisons.
BPC-157 is a synthetic pentadecapeptide (15 amino acids) isolated from human gastric juice protein BPC. It demonstrates…
CJC-1295 without DAC (Modified GRF 1-29) is a GHRH analogue with four stabilising amino acid substitutions that extend i…
IGF-1 LR3 is a synthetic analog of Insulin-like Growth Factor 1 (IGF-1) with a 13-amino-acid N-terminal extension and a…
Ipamorelin is a selective pentapeptide growth hormone releasing peptide (GHRP) that stimulates pituitary GH release with…