Dr. Adam Sewell, MD breaks down inflammaging — the persistent, low-grade inflammation that accelerates degeneration across the body's systems — and what actually moves the needle on it.
Listen →Andrew Huberman talks with mitochondria researcher Dr. Jared Rutter (University of Utah, HHMI) about how mitochondria generate cellular energy, regulate cell growth and division, and link to aging and cancer. The conversation frames metabolism as an emergent property of trillions of individual mitochondria-containing cells.
Listen →Dr. Martin Picard (Columbia) explains how mitochondria translate behavior, psychology, and mindset into cellular energy production, and how exercise, nutrition, sleep, and stress reduction measurably affect mitochondrial function and aging markers.
Listen →Dr. Martin Picard (Columbia) explains how mitochondria translate behavior, psychology, and mindset into cellular energy production, and how exercise, nutrition, sleep, and stress reduction measurably affect mitochondrial function and aging markers.
Listen →Three geroscientists (rheumatology, neurology, and critical care) map how chronic low-grade inflammation shows up across specialties — from rheumatologic disease to traumatic brain injury — and where the gap is between wellness-marketing claims and actual evidence on inflammaging tests and treatments.
Listen →Eric Verdin, CEO of the Buck Institute for Research on Aging, on how immune aging — thymic shrinkage, narrowing T-cell diversity, weaker vaccine response — acts as a rate-limiting step in aging, and how chronic inflammation is both a consequence and an accelerant of it. Also covers NAD decline and CD38, the real limits of NMN/NR/IV NAD, rapamycin, and what aging clocks can and can't tell you.
Listen →Ralph DeFronzo, M.D. walks through the pathophysiology of insulin resistance across muscle, liver, and fat, and how it's measured, prevented, diagnosed, and treated.
Listen →Ralph DeFronzo, M.D. — the researcher who helped bring metformin to the US and developed SGLT2 inhibitors — walks through the pathophysiology of insulin resistance across muscle, liver, and fat, and how it's measured, prevented, diagnosed, and treated.
Listen →Huberman and Attia dig into the NAD+ pathway, comparing NAD, NMN, and NR supplementation, routes of administration, and what the clinical literature actually supports for longevity.
Listen →Attia and Huberman work through the research on metformin as a longevity drug. Along the way Attia explains how insulin resistance develops — starting in muscle — and its role in type 2 diabetes. A useful look at how to read the evidence behind a much-hyped intervention.
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